What is Rejuran treatment? An honest Canadian guide
Ariana Wen
July 5, 2026
Key takeaways
Rejuran is an injectable made from purified salmon DNA — regeneration, not a filler.
It works by prompting your own skin cells to make collagen.
Confirm three things before booking: Canadian availability, Health Canada status, and CAD cost.
What is Rejuran treatment, really?
If you have searched "what is Rejuran treatment" and hit a wall of foreign clinic pages, here is the plain answer. Rejuran is an injectable skin-rejuvenation treatment. Its active ingredient is PDRN — polynucleotides, or long strands of DNA — drawn from purified salmon DNA. Clinics note that salmon DNA shares about 97% similarity with human DNA, which is the reason it sits well in human skin. The fragments used are described as more than 95% pure, taken from wild salmon reproductive cells.
One honest caveat up front: these definitions come from clinic marketing pages, not an independent lab. So read the mechanism below as how Rejuran is described to work, not as something this page has verified for you.
How it works under the skin
Most skincare sits on top of the skin. Rejuran is pitched as doing something different. Polynucleotides are natural DNA fragments that, per the sources, trigger cell repair. They stimulate fibroblast activity and push the skin to make more collagen and elastin. Fibroblasts are the cells that build your skin's support structure. The idea is renewal from within, not a surface glow you wash off.
That said, the mechanism claims trace back to clinic sources here, not to primary peer-reviewed studies in front of us. Treat fibroblast-and-collagen as the proposed mechanism — well described, but not independently proven on this page.
What's clinically established vs. what clinics market
This is where the foreign search results get slippery, so let me draw the line clearly.
Reasonably established: PDRN and polynucleotides are described across several sources as stimulating fibroblasts and collagen. That is the consistent, coherent part of the story.
Marketed but not proven here: phrases like "glass skin," "clinically proven," and results that "last months to a year." One Thai clinic page states Rejuran is "certified by the Thai FDA and supported by multiple scientific studies," with nothing to check. This page will not repeat that. A claim you can't trace isn't a claim; it's a slogan. Where clinics cite Korean dermatology journals to prove tissue repair, we found no sourced reference, so we leave it out.
The honest limit: the line between established and marketed is only as sharp as the evidence, and here the evidence is clinic-sourced. We draw it conservatively and send you to a clinician for anything past it.
Which Rejuran formula matches which concern
Rejuran is sold as a small family of formulas, each aimed at a different concern.
Formula: Rejuran Healer / What it targets: The original formula; general skin rejuvenation
Formula: Rejuran S / What it targets: Made for acne scars
Formula: Rejuran i / What it targets: Tailored for the delicate under-eye area
Formula: Rejuran HB / What it targets: Combines polynucleotides with hyaluronic acid
Formula: Rejuran HB PLUS / What it targets: A newer combination option
One catch: formula names and availability shift by market. A formula listed on an Australian or Korean page may not be the one — or the name — a Canadian clinic offers. Confirm which product is actually on the shelf where you book.
What to expect: sessions, timeline, and downtime
Plan for a course, not a single visit. One clinic source describes a typical series of 3 to 4 sessions, spaced 2 to 4 weeks apart. Visible changes, like smoother texture and a healthier look, are commonly reported within 2 to 4 weeks.
Two honest notes. This schedule comes from a single source and describes what is "often recommended," not a guaranteed plan or result; individual plans differ. And this page's evidence doesn't detail downtime or aftercare, so ask your clinic exactly what the days after an injection look like.
Typical course: 3–4 sessions spaced 2–4 weeks apart; visible improvements commonly start around 2–4 weeks.
Rejuran vs. fillers, Botox, and the other injectables people ask about
The cleanest way to place Rejuran is by what it does to the skin, not by a feature list. Fillers add volume. Botox relaxes the muscle that creates a wrinkle. Rejuran does neither. It is meant to stimulate collagen and help the skin repair itself. That mechanism is the deciding difference.
It also tells you where Rejuran is the wrong tool. If you want to plump a hollow cheek or soften a dynamic frown line, Rejuran is not built for that job.
People also ask how it compares to exosome therapy, PRP, and Juvelook. Here I will be straight: this page has no sourced, head-to-head comparison of their mechanism, evidence, and duration, so it won't hand you a "which is better" verdict. That is a real question for a clinician who can see your skin.
Is Rejuran right for you?
Rejuran tends to interest people focused on skin texture, early aging, and acne scarring — the regeneration lane rather than the volume lane. But candidacy is a medical decision, and this page's evidence does not include a full, sourced list of who should skip it.
So treat these as questions to raise, not rules stated here. Pregnancy or nursing, a history of keloid scarring, autoimmune conditions, and recent isotretinoin use all come up in aesthetic consultations. This page won't assert any of them as a hard yes or no, because the product monograph that would settle it isn't in front of us. Bring them to the clinician.
What to confirm before you book in Canada
Almost every page ranking for this treatment is foreign — Australian, Thai, Korean, American — priced in AUD, THB, or KRW and citing the Thai FDA. None of that helps a Toronto reader. Here is the short checklist to bring to a Canadian consultation.
Product authenticity and availability. Confirm the clinic uses genuine Rejuran, and ask which formula it actually stocks.
Health Canada status. One Canadian clinic page claims Rejuran Healer was Health Canada registered in 2019. This page treats that as unverified. Ask the clinic to show the product's current Canadian regulatory standing rather than taking a marketing line for it.
CAD cost. Get the price per session and for the full course in Canadian dollars. No verified Toronto price exists in this page's sources, so don't anchor on a foreign figure.
To be clear about this page's limits: it does not confirm Rejuran's Health Canada status, and it does not price the treatment for you. Those are the two things only a local clinic can answer.
Your next step
If regeneration — not volume — is what you are after, the next move is a consultation, where that Canada checklist actually gets answered. Bring three questions: is the product genuine and available, what is its Health Canada standing, and what is the full CAD cost. A consultation confirms fit and price; it is not a commitment to treatment.
If you want to compare approaches first, it is worth reading up on collagen-stimulation options in Toronto and, if scarring is your main concern, acne scar treatment in Toronto. When you are ready, book a consultation to get your checklist answered.